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Ozempic and Weight Loss: Everything You Should Know Before Starting

Jun 26, 2025

Primary Care

Ozempic and Weight Loss: Everything You Should Know Before Starting

Ozempic is a prescription medication that’s become increasingly popular for its role in weight loss. Approved initially to manage type 2 diabetes, it’s now being widely prescribed off-label to help people lose significant weight. However, before considering the addition of Ozempic to your routine, it's essential to understand how it works, its intended use, potential side effects, and the results you can expect.

In this blog, we’ll cover everything you need to know about Ozempic for weight loss so you can decide if it’s the breakthrough you’ve been searching for.

What Is Ozempic?

Ozempic, a prescription drug that contains semaglutide, a GLP-1 receptor agonist originally developed to manage type 2 diabetes. It works by imitating a hormone that helps stabilize blood sugar, slow gastric emptying, and suppress hunger. 

It’s often confused with Wegovy, but there’s a key difference:

Wegovy also contains semaglutide but is FDA-approved specifically for weight management and prescribed at higher doses than Ozempic. 

In short, Ozempic is a diabetes medication used off-label for weight loss, whereas Wegovy is specifically designed and approved for this purpose. Both are widely used today.

How Does Ozempic Work for Weight Loss?

Ozempic contains semaglutide, a compound that mimics the hormone GLP-1 (glucagon-like peptide-1), which regulates appetite, digestion, and insulin levels. By mimicking the effects of GLP-1, Ozempic enables the body to respond differently to food and supports sustained weight loss.

Here’s how it works:

  • Suppresses appetite by targeting hunger centers in the brain
  • Slows gastric emptying, keeping you full longer
  • Improves insulin response, stabilizing blood sugar and reducing cravings

Clinical trials have shown an average weight loss of 10–15%, particularly when combined with healthy lifestyle changes.

Who Is Ozempic Recommended For?

Ozempic is generally recommended for individuals who meet the following criteria:

It's essential to note that Ozempic is not intended for individuals seeking to lose a few pounds for cosmetic purposes. This medication is designed to help those struggling with obesity or significant weight-related health concerns.

Before starting Ozempic, it’s essential to consult with your healthcare provider, who will evaluate your overall health, discuss potential risks, and determine whether it’s the right treatment for you.

Dosage and How It’s Taken

Ozempic is given as a once-weekly injection, usually in the thigh, upper arm, or abdomen. Dosage typically follows this titration schedule:

  • Starting dose: 0.25 mg once a week for the first 4 weeks (not for weight loss but to minimize side effects)
  • A gradual increase to 0.5 mg, then possibly to 1 mg or higher, depending on individual response and tolerability

Ozempic Result for Weight Loss

The amount of weight loss varies depending on factors like diet, exercise, and individual response to the medication.

Timeline for Results:

  • Weeks 1-4: Most people start feeling less hungry and may notice some weight loss within the first month.
  • Months 2-6: Significant weight loss typically occurs, with continued appetite control and improved eating habits.
  • Beyond 6 months: Continued weight loss or weight maintenance, depending on individual goals.

For optimal results, Ozempic should be paired with a healthy eating plan and regular exercise.

Common Side Effects and Risks

Ozempic may cause side effects, especially during the early weeks. Common ones include nausea, fatigue, constipation, diarrhea, and stomach discomfort, which typically improve over time.

In rare cases, serious issues like pancreatitis, kidney problems, or gallbladder disease may occur.

Avoid Ozempic if you have a history of thyroid cancer, MEN 2, or are pregnant or breastfeeding.

Lifestyle Results for Better Results

To maximize the benefits of Ozempic and reduce side effects, consider the following tips:

  • Diet: Focus on consuming small, high-protein foods that keep you full longer. Avoid overeating, as Ozempic helps control your appetite.
  • Exercise: Regular physical activity can help boost weight loss and improve overall health.
  • Hydration: Proper water intake helps keep your digestion smooth and prevents constipation.
  • Mental health: Stay motivated and maintain a positive outlook. Long-term success starts with consistent healthy habits.

Find the Right Weight Loss Support at MI Express Primary Care

Ozempic may help effectively manage obesity and support weight loss, but it works best when combined with healthy habits and professional guidance. It’s not a quick fix but part of a long-term, personalized plan. Consulting a healthcare provider is key to ensuring it’s the right choice for you.

At MI Express Primary Care in Canton and Ann Arbor, MI, your goals become our mission. Our experienced team will guide you every step of the way with a weight loss plan tailored to your unique needs. 

Achieve your goals with expert care. Schedule your consultation today to explore our personalized weight loss programs, including medical supervision, diet planning, and ongoing support.

Ozempic and Weight Loss: Everything You Should Know Before Starting
Ozempic and Weight Loss: Everything You Should Know Before Starting
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